Previous work from our laboratory reported that aggressive melanoma and breast carcinoma express the embryonic morphogen Nodal, which is essential for human embryonic stem cell (hESC) pluripotency.
然而,癌症环境缺乏合适调控机制来维持一个正常表型。
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In 2011 Yoshiki Sasai of the RIKEN Centre for Developmental Biology, in Kobe, showed how mouse embryonic stem cells, if mixed with a few appropriate growth factors, quickly form a three-dimensional cluster made of the precursor cells to neurons.
左使良树(Yoshiki Sasai)任职于神户(Kobe)理化研究所发育生物学中心(RIKEN Centre for Developmental Biology)。他于2011发表论文,阐述了老鼠胚胎干细胞在给予一些适当生长因子后,快速形成一个三维立体簇集物过程。
So we wanted to understand the biological program running inside an embryonic stem cell, and understanding the computation performed by a living system starts with asking a devastatingly simple question: What is it that system actually has to do?
所以我们想要了解在 ES 细胞中运行生物程序,而且,了解该生物系统中所运行计算始于提出一个极为简单问题:这个系统到底需要做什么?